Showing posts with label genetics. Show all posts
Showing posts with label genetics. Show all posts

Thursday, August 25, 2022

Our Viral Symbiotes

About 8% of our DNA may have come from ancient viruses that infiltrated our cells, where they established permanent residence.

Viral "Fossils" in Our DNA

The human genome includes 100,000 pieces of "ancient viral DNA." Recent studies of what function, if any, this "fossil" DNA might perform in our bodies suggest that it may play a vital role in boosting our immune systems. Amazingly, viruses that invade our cells sometimes not only become part of our chromosomes but become inheritable. The article summarizes the process thusly:

"When a type of virus known as a retrovirus infects a cell, it converts its RNA into DNA, which can then become part of a human chromosome. Once in a while, retroviruses infect sperm and egg cells and become 'endogenous,' meaning they are passed down from generation to generation."

In science-fiction treatments of traditional monsters such as vampires and werewolves, this ability of some retroviruses could be invoked to rationalize how a naturally evolved creature of a different species could convert a human victim—or willing host—into a member of the "monster" species.

When Walt Whitman declared, "I contain multitudes," he wrote truer than he could have suspected. That quote features in the title of a book by Ed Yong, I CONTAIN MULTITUDES: THE MICROBES WITHIN US AND A GRANDER VIEW OF LIFE, about microbiomes inside animals and especially humans, in the context of a vision of our bodies as "living islands" with millions of inhabitants.

On a totally different topic, but harking back to some of my earlier posts, here is a detailed article about the intelligence of octopuses, to which I've alluded more than once in the past. As the article says, they're probably the closest to intelligent aliens of any species we currently know. Cool!

Another Path to Intelligence

Margaret L. Carter

Carter's Crypt

Thursday, January 23, 2020

Anticipating Androids

In Mary Shelley's novel, Victor Frankenstein apparently constructed his creature by stitching together parts of cadavers. (His first-person narrative stays vague on the details.) Considering the rapid decay of dead flesh as well as the problem of reanimating such a construct, if we ever get organic androids or, as they're called in Dungeons and Dragons, flesh golems, they're more likely to be created by a method similar to this: Robotics experts at the University of Vermont have designed living robots made from frog cells, which were constructed and tested by biologists at Tufts University:

Xenobots

They're made of living cells derived from frog embryos. Joshua Bongard, one of the researchers on this project, describes the xenobots as "a new class of artifact: a living, programmable organism." The frog cells "can be coaxed to make interesting living forms that are completely different from what their default anatomy would be." Only a millimeter wide, they potentially "can move toward a target, perhaps pick up a payload (like a medicine that needs to be carried to a specific place inside a patient)—and heal themselves after being cut." They might also be able to perform such tasks as cleaning up radioactive materials and other contaminants or scraping plaque out of arteries. While this process doesn't amount to creating life, because it works with already living cells, it does reconfigure living organisms into novel forms. Although there's no hint of plans to build larger, more complicated artificial organisms, the article doesn't say that's impossible, either.

If an android constructed by this method could be made as complex as a human being, could it ever have intelligence? In an experiment I think I've blogged about in the past, scientists at the University of California, San Diego have grown cerebral "organoids"—miniature brains—from stem cells:

Lab-Grown Mini-Brains

These mini-brains, about the size of a pea, can "mimic the neural activity" of a pre-term fetus. Researchers hope these organoids can be used to study brain disorders and perhaps to replace lost or damaged areas of living human brains. At present, they can't think or feel. But suppose they're eventually grown large and complex enough to—maybe—develop sentience or even consciousness? In that case, it could be reasonably argued that they should have individual rights. The "disembodied brain in a jar" that's a familiar trope of SF and horror, is, according to the article, a highly unlikely outcome of this research. If these miniaturized brains ever became complex enough to transplant into a more highly developed version of the frog-cell "xenobots," however, the question of personhood would surely arise.

Margaret L. Carter

Margaret L. Carter

Thursday, August 29, 2019

Biology and Free Will

The September issue of NATIONAL GEOGRAPHIC features a short piece titled "Why You Like What You Like." It explores the biological basis of likes and dislikes, attraction and repulsion. It cites the discovery that the Toxoplasma organism can make rats unafraid of cats and may possibly cause "increased anxiety" in humans. Other examples of biological influences on tastes and behavior include genetic links to aversion to broccoli, preferences in sexual partners, and conservative or liberal political tendencies.

The author expresses dismay at the realization that he's been wrong all this time in believing "my likes and dislikes were formed through careful deliberation and rational decision-making." The findings detailed in this article don't come as that much of a shock to me. It seems like an obvious truism that most of the time we "can't help" liking or disliking things or people. As for political, philosophical, or religious tendencies, our genes may predispose us to see the world a certain way, but surely they don't totally control our choices. The article itself acknowledges this fact, because "embedded within your genome, there are many potential versions of you." The science of epigenetics has revealed many environmental factors that influence the way genes are expressed; chemicals, protein interactions, and even the microbes living inside us can affect our DNA. Those influences still imply that we don't have the conscious control we think we do, though.

"There are biological gremlins driving every action and personality trait that you assumed were of your own volition." Again, I've never assumed my personality traits were chosen by my "own volition," and I doubt many people think that way. Personality comes as part of the start-up package. Moreover, "driving" doesn't necessarily mean "controlling." After this somewhat pessimistic summary of the evidence, the author acknowledges that very fact and assures us we aren't "destined to be slaves of our DNA." With heightened awareness of how genes and other biological factors shape our minds and behavior, we may develop more efficient ways to change the traits we consider undesirable. So he does allow room for free will. So do the scientists who maintain that consciousness itself is an illusion, by the very act of making that claim. For an illusion to exist, there must be a mind—a consciousness—to embrace that illusion.

Even at the mid-twentieth-century heyday of the "blank slate," radical malleability of human character, environment-is-destiny position, one of the primary fictional exemplars of that belief, BRAVE NEW WORLD, allows for free will. At least one character conditioned from the moment of conception to fit into Huxley's utopia of programmed happiness questions his society and its culture. Our ability as authors to write interesting stories would be severely limited if we and our readers believed our characters couldn't have any freedom of choice.

Margaret L. Carter

Carter's Crypt

Tuesday, October 16, 2018

Reviews 40 - John Dixon The Point

Reviews 40
The Point
by
John Dixon



Reviews have not yet been indexed.  I discuss many novels within the context of various writing techniques they illustrate, and a few (40 so far) separately, to be referred to later.

Today, I have a novel -- mostly Urban Fantasy -- by John Dixon from Del Rey books -- which was sent to me (free) in ARC form via Amazon Vine.

I review products for Amazon which they send out free samples to promote.  The deal is the reviewer pays the income tax on the wholesale price of the item, so it isn't really free, but the slug at the top of the review identifies the Vine Voice -- meaning, getting the item free, they might not be as critical as they should be.

I will post an Amazon page review of this novel, John Dixon's THE POINT, using most of what I have to say here, but the Amazon page comments are not "reviews" and not aimed at Romance readers or Romance writers looking to deepen their craft skills.

THE POINT - by John Dixon, is an attempt at a new angle on the "posthuman" or mutant human who gets "superpowers."

It is of interest to Romance Writers (probably not to READERS of Romance genre) because the main female kick-ass Character experiences a glancing infatuation after bouncing around among sexual encounters and the drug scene.  Having no home life to compare her feelings with, she risks her standing at West Point to meet her lover at night.  That's ALL there is in this novel - a mostly off-stage Relationship between wasted and weak Characters who turn out to redirect World History.

None of the characters are "admirable" in the sense of exemplifying Values our society today adheres to without realizing they are Values.

Since all the characters are on the same moral/spiritual level, there actually is no conflict -- not internal or external.  Conflict is the essence of both story and plot -- but this novel has neither.

This makes the book worth studying because it was published in August 2018 by Del Rey in Hardcover etc.  This prestigious publishing house expects broad audience appeal.  I don't think so -- but they might sell the movie rights.

Why would it make a movie, though it fails as a text story?

Because though there isn't much sex, there is Violence, and ESP powers that allow for burning, ugly events, explosions, levitation, and overpowering the Will of others, even in large groups.

There is lots of visual interest loosely glued together by a narrative line.

You don't "live" the growth experiences of these Characters, and learn their life lessons vicariously.  You are TOLD (not shown) that the Characters change their minds about how to live, usually under the hammer of Authority and threats of jail.

They "are forced" to West Point where they are press-ganged (legally) into a secret program (actually housed under ground at West Point) run by a guy who instigated the genetic mutation that caused them to be born with "powers."  Each has a different sort of "power."

This guy, the backstory reveals slowly, was in charge of a unit that got poisoned in a war theater, med-evaced to a place where experimental methods were used to "cure" them.  The children of those soldiers were born with "powers."

This is the oldest form of "science is evil" novel.

These Characters are the product of Science, and not a one of them has any sense of "right vs. wrong" -- just expediently adopting whatever ideas are floating around them.  They eventually adopt the ideals of West Point -- but there is no foundation for this philosophy.

There is no reason for these Powered People to loyally defend their country, except that their country has press-ganged them and brainwashed them.

There is a wan, half-hearted attempt at the end to enunciate the Values that West Point is based on, but it fails because it is all tell and no show.  And the infatuation which flickers randomly through the course of events is not a Soul-Mate driving force, bringing a flash of true illumination to the Souls of the couple.  There is no reason, other than being defeated by force, to adopt the Values of West Point or Patriotism in any form.  Nothing "good" is revealed about government.  There is no hint that these people will not switch loyalties again at the first challenge because there's no reason for them to become loyal to the government. 

Some of the products of this guy's experiment wash out of "The Point" program, and are sent to "The Farm" where they are imprisoned because they are too dangerous to release.  They escape and form the opposition the recruits at The Point are being trained to overcome.

One guy, some wild science experiments, and two factions are generated who strew the landscape with destruction.

The Point is the stuff Hollywood looks for, but not what novel readers seek.

Jacqueline Lichtenberg
http://jacquelinelichtenberg.com

Thursday, April 06, 2017

Accelerating Human Evolution

If you have a chance, pick up the April 2017 issue of NATIONAL GEOGRAPHIC and check out the cover article, "The Next Human." Contrary to popular belief, the human species hasn't stopped evolving. This article mentions several examples of recent evolutionary change, such as the two most widely known: While most ethnic groups lose the ability to digest milk in adulthood, a few have developed adult lactose tolerance, which led to cultures based on dairy herds. The gene for sickle cell anemia causes a serious disease when doubled, but inheriting only one copy of the gene seems to provide resistance against malaria. Adaptations less familiar to the general reader include populations living at high altitudes who have evolved a hemoglobin trait that enables them to use oxygen more efficiently and desert dwellers who can handle a wider range of temperature extremes than most people.

Evolution doesn't have to wait for the slow processes of nature anymore, though. Technologies such as CRISPR can alter genes to order. Few people would object to using genetic engineering to correct disabling or lethal inherited conditions. But what about choosing an embryo's eye and hair color or trying to enhance intelligence in utero?

The article, however, also explores technological advances that adapt users to the environment in ways natural processes alone can't. One man born with achromatopsia—he's literally color-blind, seeing only blacks, whites, and grays—has an antenna attached to a sensor in his brain that enables him to perceive colors. Not only that, he goes beyond ordinary human vision to "see" infrared and ultraviolet. Hundreds of people have been implanted with devices that allow them to unlock doors or log onto computers without touching anything. The University of Southern California is running tests on "chip implants in the brain to recover lost memories."

Does becoming a cyborg count as a form of "evolution"?

Margaret L. Carter

Carter's Crypt

Thursday, March 16, 2017

We're All Mutants

This article on the SCIENTIFIC AMERICAN MIND site uses the "X-Men" series as a springboard for an overview of genes and mutations:

We're All X-Men

Popular culture tends to think of "mutants" as extraordinary freaks of nature to be either feared or envied (in superhero stories, often a bit of both). Yet alterations in DNA are common and pervasive. The article estimates that human beings "accumulate 100 to 200 mutations each generation." Some changes, while nowhere near as amazing as Wolverine's super-healing power, have had far-reaching cultural effects; think of the fact that, while most ethnic groups have lost the ability to digest milk in adulthood, a few have retained lactose tolerance all their lives—so we have dairy products and herding societies. Some mutations are both good and bad. The gene that causes sickle cell anemia also offers protection against the malaria parasite.

Recommended reading: A book titled FREAKS OF NATURE: WHAT ANOMALIES TELL US ABOUT DEVELOPMENT AND EVOLUTION, by Mark Blumberg, explores "monsters" in human and animal development, whether produced by genetic mutations before conception or by environmental influences or developmental glitches during gestation. As the subtitle indicates, studying "monstrosities" can provide insight into the normal course of development in an individual or species. For example, one chapter analyzes the way malformations of limb development in many different animals can be caused by either environmental toxins or changes in DNA, yet the underlying cellular processes that produce anomalies or absence of limbs are similar, whether in people or animals born with missing arms or legs or in naturally limbless snakes.

Without variations for evolution to work on, we wouldn't be here, since life on Earth wouldn't have changed from the primeval, microscopic proto-organism. As the SCIENTIFIC AMERICAN MIND article says, the electronic mutant detector in one of the "X-Men" movies "wouldn’t have just identified Mystique as the camouflaged mutant; it would registered all of the humans in the room as well." On the cellular level, we're all mutants.

Margaret L. Carter

Carter's Crypt

Thursday, September 01, 2016

Human Hybridization

It's now widely believed that early Homo sapiens crossbred with Neanderthals. Here's an article speculating on why interbreeding may have happened:

Human Hybridization

Offspring from mates of two different species often display "hybrid vigor." This author also suggests (using the example of mules) that a hybrid may have higher intelligence than either ancestral species.

These factors show that interbreeding may bestow advantages on the offspring; however, they don't explain why individuals would be motivated to mate with other-species partners. Mistaken identity? As a last resort when members of their own species aren't available? From positive attraction?

In one of my favorite novels, CLAN OF THE CAVE BEAR, Cro-Magnon (Homo sapiens) child Ayla, adopted by Neanderthals, grows up to bear a Cro-Magnon-Neanderthal baby. Her pregnancy results from rape. Like the rest of the clan, the father of her child considers her ugly, or at least odd-looking, and he rapes her to assert dominance, not from desire. Because human babies are born less developed than Neanderthals, Ayla's adopted people think her infant son is deformed. At birth he can't even hold up his head! As he matures, of course, he outstrips his Neanderthal kinfolk in many ways. (As a child, Tarzan in the original novel fares similarly among the apes, who at first take a dim view of she-ape Kala's adopting a hairless, frail creature that will obviously never be able to care for itself. Burroughs' series, by the way, assumes that his "great apes"—definitely not gorillas, which are shown as lesser animals, so the great apes must be a "missing link"—are related closely enough to human beings to interbreed, as seen in Tarzan's visits to the ruined lost city of Opar.) In later books, Ayla learns that other hybrid children exist, usually conceived by rape of Neanderthal girls by gangs of Cro-Magnon men. She speculates that her son may have to look for a mate among these crossbreeds, since both types of human beings often view "children of mixed spirits" as abominations.

James Tiptree's story "And I Awoke and Found Me Here on the Cold Hill's Side" postulates that human beings have a powerful exogamous drive. We're drawn to exotic partners because, in prehistory, marrying out of the tribe kept the genes circulating. A girl's elopement with a boy from the strange people on the other side of the mountain gave evolutionary benefits to her descendants. In Tiptree's story, this impulse has gone wild and become a liability as human beings traveling among the stars pursue the irresistible attractions of exotic aliens, with whom no fertile mating is possible.

Science fiction teems with fascinating human-alien hybrids, such as Spock. In most cases, the writer and reader simply agree to suspend disbelief in inter-species crossbreeding, with no inconvenient mention of incompatible genes. Larry Niven's well-known essay "Man of Steel, Woman of Kleenex" uses Superman and Lois Lane to highlight how improbable this crossbreeding would be. To make such characters biologically plausible, the author would have to assume the galaxy was purposely "seeded" with life from a single point of origin or perhaps that meteors transported DNA through interstellar space.

Margaret L. Carter

Carter's Crypt

Thursday, March 10, 2016

Is Monogamy a Good Idea?

Some biologists don't think it is:

Pairing Up for Life

Many species of birds are known to pair up for one breeding season or for life. The main reason is that their newly hatched chicks need the constant labor of two parents to keep them fed and alive. But DNA tests show that most of them practice only social monogamy, not sexual monogamy. "Adultery" is not at all uncommon among birds. "Unfaithful" females benefit from the best of both lifestyles; they get mated partners to help raise the chicks and also a more varied genetic contribution to their offspring than they would receive from their mates alone.

In mammals, as the article points out, it's impossible (without bottles and formula, at least) to divide parenting duties equally between male and female. Gestation and breast-feeding help to account for the much lower frequency of monogamy among mammals.

Elaine Morgan's THE DESCENT OF WOMAN outlines the factors common to most species that practice pair-bonding: (1) Helpless infants who require intensive care in early life. (2) A den, nest, or other fixed location where the young are sheltered. (3) Approximate equality between male and female rather than overwhelming male dominance (which the BBC article also mentions).

An additional, rather grim purpose for pair-bonding arises from the tendency of males of many species to kill infants sired by other males. A female with a permanent mate has protection for her babies against marauding outsiders.

On Marion Zimmer Bradley's Darkover, the original colonists from the stranded ship in DARKOVER LANDFALL recognize the perils of settling a new world with a limited gene pool. Therefore, in the early generations of Darkovan society, women are encouraged to bear children by as many different men as possible rather than entering into exclusive marriages. Of course, they also receive an outside genetic contribution from the chieri.

Despite the benefits of genetic variation to the family and the species, faithful monogamy remains the ideal in our culture. Most of us probably believe the social, spiritual, and emotional motives for love and marriage outweigh the advantages of spreading our DNA abroad.

Margaret L. Carter

Carter's Crypt

Tuesday, October 12, 2010

Genetic Mechanism By Which Love Conquers All

Looking for an article posted online because I had browsed it in a waiting room in a paper copy of DISCOVER magazine, I got stuck reading this article:

http://discovermagazine.com/2010/jun/15-brain-switches-that-can-turn-mental-illness-on-off

See, that's the problem with being "a reader" -- doesn't much matter what words are stuck in front of one's nose, you'll read them. Dictionaries, Encyclopedias, 3 thousand year old grocery lists, doesn't matter. Everything is fascinating to a writer.

That's one of the ways you know you're a writer. Everything implies something that could make a story.

So I got stuck on this article on mental illness, a subject which bores me stiff, so of course I got all excited about the Romance story potential in it.

------Quote From Discover--------

Each of our brain cells contains the same set of genes we were born with and uses those genes to build proteins and other molecules throughout its life. The sequence of DNA in those genes is pretty much fixed. For experiences to produce long-term changes in how we behave, they must be somehow able to reach into our brains and alter how those genes work.

Neuroscientists are now mapping that mechanism. Our experiences don’t actually rewrite the genes in our brains, it seems, but they can do something almost as powerful. Glued to our DNA are thousands of molecules that shut some genes off and allow other genes to be active. Our experiences can physically rearrange the pattern of those switches and, in the process, change the way our brain cells work.
------END QUOTE-------------

So then I read the beginning of the article which explains how lab experiments with mice show that a baby mouse that got attention from its mother (licking its fur) grows up to be harder to startle and more willing to explore while a baby mouse that didn't get attention grows up to be a scaredy cat.

Receiving affection changes you. 

I haven't found experiments on how giving affection changes you but I bet it does.

The article does describe how certain proteins stuck to or surrounding certain genes control whether that gene expresses in your body, or not.

GENES are not DESTINY.

Genes may set up the dropdown menu from which your life-choices are made, but experiences can "gray out" items on that dropdown menu.

In other words, they are getting close to solving the problem of "Nature vs. Nurture" and the solution they see right now is the one I've always thought the most likely -- it's not either-or, it's both-and.

Nature (your genes, your astrological natal chart, your starting conditions you can't change now) does set up parameters which govern the shape of your life. But nurture - the things that happen to you, that you draw from your environment by dint of being you - can alter the way your Nature expresses itself.

Then I saw this article on a Discover blog taking another "discovery" to task for being ill designed and executed:

http://blogs.discovermagazine.com/gnxp/

----QUOTE blog--------

that around ~30% of the outcome of financial decisions are heritable. That is, that ~30% of the variation in financial decisions within the population can be accounted for by variation in genes within the population.

-----END QUOTE-------


The blogger challenges the connection between genes and financial decisions, and I don't buy that connection either.

BUT WHAT IF....?????

It makes a great SFR premise, doesn't it?  Your wealth is genetic? 

-------Quote blog--------
Over time shared home environment, what your parents model and teach you, tends to wear off, and gene-environment correlation increases the correspondences between particular genetic makeups and behaviors (i.e., identical twins resemble each other more at maturity than in their youth). For most behavioral traits heritability increases with age.
-------End Quote---------

The idea that your original nurture effect wears off with the years does not correlate well with the idea that these proteins wrapped around your genes can cause the genes to express or not express, and that can be determined by nurture - and changed later by experience or therapy.

In other words, human personality remains PLASTIC through life.

If that's true, then love counts. Finding your soul-mate can change everything. Finding your connection with the Divine can provide the strength to kick an addiction and change your life.

Back to the Discover article on mental illness.

Look at the last page of the article. "Epigenetic" is the term for the proteins bound around genes that control whether the gene expresses. 

-------Quote Discover---------
Depression, for example, may be in many ways an epigenetic disease. Several groups of scientists have mimicked human depression in mice by pitting the animals against each other. If a mouse loses a series of fights against dominant rivals, its personality shifts. It shies away from contact with other mice and moves around less. When the mice are given access to a machine that lets them administer cocaine to themselves, the defeated mice take more of it.
--------End Discover Quote------

The article then describes work on brains of deceased humans, some who lived out normal lives and some who committed suicide, showing a difference very similar to the differences found in defeated mice. The article ends with work done on mice that were depressed by being defeated. An injection into the brain caused the symptoms of depression to dissipate even in adulthood by changing the epigenetics. 

Now, nobody is going to investigate whether finding love in adulthood can change the brain chemistry of humans enough to vanquish depression or other such illnesses.

Nobody is going to investigate the effects on humans of just plain acceptance by others, or niceness in society.

But what is here does suggest that the great dust-up over bullying in school yards may have substance behind it. Being beaten up by mobs of kids can really change you and your chances of success in the world.

Some other kind of experience may predispose humans to diving into a cycle of poverty, gambling, or being unable to hold a job.

There may be more kinds of "assassination" than simply murdering someone, or "character assassination."

It may be that simple unkind words can destroy a life.

Speaking unkindly about anyone may in fact be an act of aggression that has dire consequences.  Maybe it might have consequences to the speaker.

If that's true, then a kind word may save a life, perhaps your own.

Do any of the writers here see the PNR applications to the novel structure element called CONFLICT?  If you write Urban Fantasy with magical rules, this kind of "magic" can make a great conflict source, thematic source, character quirk, or plot.  And we're not even touching on love potions and the ethics behind that.

Faith Healing is for real?

Can you heal yourself by changing your opinion of yourself?

How do you go about that? Do you need help from outside? Can the help of a clinician really do the trick? Or do you need true love?  Or will you resort to an injection into the brain? 

Is the real barrier to finding true love somehow in your brain chemistry itself? Do you need an injection into the brain in order to be capable of pair-bonding?

The SF possibilities for SFR are endless here.

What about kids decanted from artificial wombs then raised in a creche among mostly other kids?

What about kids raised in total isolation from other kids?

If you've been following the developments in nano fabrication, you can see how close we are to having brain implants that can do things like fix blindness and deafness caused by brain malfunctions. All kinds of nano-implants for various purposes are ridiculously close. Research money is currently pouring into projects to use nano-tech to bring solar-power up to where it's cheaper than say coal-fired power plant power.

The spinoff from that power research could be the brain implants, and other nerve replacements that could cure, say, paralysis.

Between implants and chemistry -- personalities can be engineered so that people grow up to have a "talent" and ability for specific jobs.  Do you want government deciding your career before you are born and tailoring you to it? 

Maybe stupidity can be cured? Maybe we can all be engineers?  Who decides? 

The question is, do we want these things imposed from outside, or are we as a society going to get busy and cure most of it with love?

Jacqueline Lichtenberg
http://jacquelinelichtenberg.com