Showing posts with label clone. Show all posts
Showing posts with label clone. Show all posts

Thursday, January 26, 2023

Clones as Organ Donors

I've recently read an excellent novel called NEVER LET ME GO, by Kazuo Ishiguro, author of THE REMAINS OF THE DAY. (I've seen the film adaptation of the latter, but I don't plan to watch the movie of NEVER LET ME GO. The story just strikes me as too depressing to view as a dramatization, without being filtered through the narrator's voice as in the book—and I generally LIKE sad stories.) NEVER LET ME GO traces the youth and coming-of-age of children cloned for the sole purpose of serving as organ donors. Kathy, the narrator, and her friends have always known, on some level, what their purpose and inevitable destiny are, but their vague awareness becomes more explicit as they grow to adulthood. The reader learns about their world along with them, through extended reminiscences by Kathy, who as a young adult serves as a "carer" for other donors until she eventually has to assume the latter function herself. She knows once she progresses from carer to donor, she will probably live through three or at most four donations before she "completes," i.e., dies. The clones don't serve as donors for the specific individuals whose DNA they share (whose identities, of course, they never know) but as general organ banks. The characters we follow grow up in a sort of orphanage / boarding school, where they live a fairly good life; they later learn that theirs is one of the best group homes, whereas others treat their inmates worse. We never learn details about the other homes, the background of the cloning project, or the science underlying it. Nor do we find out how the public was induced to accept this radical development. The novel seems to take place in an alternate mid-twentieth-century. This version of England has pre-cellphone, pre-internet technology, yet judging from the apparent ages of older donors mentioned in passing, reliable human cloning has existed for well over twenty years.

The novel focuses on the relationships among the characters, their gradual discovery of the full truth about their own status, and the ethics of treating human beings as manufactured products. Therefore, it doesn't delve into the scientific dimensions of the cloning process. Toward the end of the book, a retired guardian (as their teachers are called) mentions controversies over whether the donors have souls. Nobody brings up the obvious fact that a clone is simply an identical twin conceived at a different time, who grows like any other person and is as human, with as much of a soul (if souls exist) as anybody else. Another unanswered question raised in the story is why the characters can't have babies. There's no biological reason for clones to be infertile. Are they genetically manipulated to be that way? Surgically sterilized in childhood?

Wouldn't it be more efficient for donors to provide spare parts specifically for the people from whom they're cloned? No risk of organ rejection that way. Some of Heinlein's imagined futures include clones produced to supply organs for their originals. In these books, it's clear the cloned bodies never come alive, are never persons at all but only inert shells. One such body is used in THE NUMBER OF THE BEAST to fake the death of Lazarus Long's mother. In principle, an individual could achieve immortality by having his or her brain transplanted into a cloned body when the birth body wears out.

For most purposes, though, why grow a whole body at all? Surely it would be easier to develop cloning technology that could generate particular organs as needed. You could get a new heart, liver, kidney, or whatever with your own DNA and with none of the ethical issues involved in mass-producing live, conscious people to serve as spare-part factories.

So, although NEVER LET ME GO raises fascinating issues, and its characters' plight is deeply moving, it doesn't seem to me a likely portrayal of a realistic scenario.

Margaret L. Carter

Carter's Crypt

Thursday, February 07, 2019

Pregnant Males

Do you follow THE ORVILLE? This TV series begins as an affectionate parody of STAR TREK (even the uniforms look similar) but—as far as I can tell from reading about it and watching the first few episodes—gradually becomes more serious. One alien officer, who lives on board with his mate, belongs to an all-male species. In the second episode, he lays an egg, which hatches in the third episode. I'm not sure why he refuses to take a break from brooding the egg; doesn't his mate help? And what about an artificial incubator? Anyway, the baby turns out to be female, a rare abnormality in this species, for which the standard remedy is an immediate sex-change operation. The serious ramifications of this problem mesh incongruously with the premise of an all-male, oviparous species, which the writers apparently introduced in accordance with what the TV Tropes site calls "the Rule of Funny." In fact, an all-male species that reproduces by itself couldn't exist. The sex that produces ova is, by definition, female. To lay eggs, people of the species portrayed in THE ORVILLE would have to be either female (reproducing by parthenogenesis) or hermaphroditic. Members of an all-male species would have to breed with females of some closely related species (as some all-female types of fish can be fertilized by males of different but not too dissimilar species).

The vintage sitcom MORK AND MINDY gets away with the pregnant alien male motif by presenting it in a funny context with no attempt at a biological rationale. Mork not only becomes pregnant, he gives birth to a "baby" who looks like an old man and, conforming to the life cycle of Mork's species, ages backward.

Octavia Butler described her classic work "Bloodchild" as her "pregnant man story." Technically, the human men don't get pregnant, though. They serve as hosts for the eggs of the centipede-like aliens who've allowed the Terran colonists to settle on their planet. When the larvae hatch, the mother removes them from the host's body before they start to eat their way out—usually.

The TV program ALIEN NATION offers a serious portrayal of how a seahorse-like humanoid male pregnancy could work. The Newcomer aliens have three sexes, including a variant type of male who penetrates the female to catalyze her fertility in some unspecified process before the father inseminates her in the "usual" way. The embryo begins to develop in the female's uterus. Part-way through the pregnancy, the fetus is transferred (in a pool of water) from the female to the male, where it grows in a pouch on the man's abdomen. The baby comes out when the pouch splits open in the course of labor.

Here's a page of speculation about how a single-sex species (female) could work in terms of Earth biology:

Single-Sex Species

In Joanna Russ's classic story "When It Changed," members of the all-female population reproduce by combining ova from two different women.

In isogamy, displayed by some life-forms such as algae and fungi, all gametes have the same size and morphology and so can be considered of the "same sex," which can't technically be labeled either male or female:

Isogamy

Some Earth organisms switch reproductive methods in alternate generations between sexual and asexual reproduction (e.g., budding).

The heroine of Megan Lindholm's CLOVEN HOOVES falls in love with a satyr she thinks of as Pan. This highly unusual novel starts out as, apparently, fantasy, in which at first we can't even be sure the paranormal encounters are happening outside the heroine's mind. Eventually, however, the story becomes SF, when the satyr reveals that he belongs to an all-male species whose members reproduce by implanting clones of themselves into human women through sexual intercourse. Thus, when the heroine gives birth to her satyr baby son, he isn't biologically related to her at all.

The occasional birth of females among the alien race on THE ORVILLE suggests a possibility for the evolution of their alleged all-male species. Maybe they once reproduced alternately sexually (through ordinary mating between male and female) and asexually (by cloning). Maybe some genetic disorder caused the conception of females to cease except in rare cases. Asexual reproduction became the only remaining viable means of perpetuating the species and came to be considered the only normal way. So when the male character in that series lays an egg, he's producing a clone of himself.

Margaret L. Carter

Carter's Crypt